Chronic Renal Failure Pt.1

Patrick lives here at the Sanctuary and receives fluids 2 times a day for his severe renal failure. He is such a sweetie that he never complains and just loves all the attention

This is Patrick our renal failure kitty. He’s a young cat but his kidneys were severely damaged by ingesting anti-freeze (extremely toxic and usually fatal for all animals!) unfortunately he will never get better. Patrick is just one of the reasons we wanted to share this information-packed series of articles with you. They were written by the staff at The Cat Doctor. CRF is such a common condition in cats that we thought it was important to pass on this valuable information.


Because of the large amount of information out there about kidney disease, we are dividing this post into a few installments. This week, we’re discussing what Chronic Renal Failure is, what the symptoms are, and how it is diagnosed. We will discuss treatment and progression in further blog posts.

Chronic renal failure, or kidney disease, is one of the most common diseases affecting older cats. In most cases, renal disease progresses slowly over time, resulting in a gradual onset of symptoms over months or even years. Regular exams and labwork can help diagnose renal disease in the early stages.

Cats with renal disease will drink and urinate more than usual

What do the kidneys do?

The kidneys have several important functions: They act as filters, ridding the body of toxins (primarily urea and creatinine) and maintaining electrolyte balance. They produce erythropoietin, which helps the body create red blood cells, and renin, which regulates blood pressure. Lastly, the kidneys produce and concentrate urine, which flushes the filtered toxins out of the body. When a cat’s kidney function is compromised, waste products build up in the bloodstream, potassium, calcium, phosphorus and sodium levels become imbalanced, and the ability to produce red blood cells and regulate blood pressure is affected. Compromised kidneys will have to work harder to rid the body of toxins, producing more urine and causing dehydration when the cat cannot drink enough water to make up for the amount she is losing.

What are the signs of CRF?

A cat with renal disease might exhibit any of the following symptoms:

  • Stevie (R) stopped grooming himself when his kidney disease advanced.

  • Increased drinking and urination
  • weight loss
  • vomiting (food or clear liquid/foam)
  • nausea/lip smacking
  • drooling
  • loss of appetite
  • muscle wasting
  • constipation
  • decreased grooming/poor hair coat
  • bad breath
  • weakness
  • dehydration
  • hovering over water dish

If you notice your kitty experiencing any of these symptoms, you should have an exam and basic labwork done to rule out kidney disease and other health issues.

What are the causes of CRF?

Persian cats are genetically predisposed to PKD

Chronic renal failure is typically a disease of older cats, though genetics, diet, and other disease processes can play a role in declining kidney function. In many cases, the kidneys simply “wear out” when the nephrons that eliminate waste products and keep electrolytes in balance begin to die off, decreasing the kidneys’ ability to filter out toxins. CRF can also be the result of genetic issues such as Polycystic Kidney Disease, which is most common in Persian-type cats. With PKD, cysts develop in the kidneys and normal function is lost. Cats can also be born with abnormalities to one or both kidneys, or with only one kidney. In these cases, the functioning kidney is under more stress than it would be in a cat with two normal kidneys.

Dental disease can contribute to CRF if left untreated; bacteria from the oral cavity get into the bloodstream and force the kidneys to work harder. It is important to your cat’s kidney health to address dental heath issues as they occur. High blood pressure can be a product of kidney disease, but it can also cause damage to the kidneys by increasing their workload. Urinary tract infections, if left untreated, can lead to kidney disease and kidney infections, and stones can cause both chronic and acute kidney disease. Regular health screening can catch theses issues before they cause too much damage.

Acute Renal Failure

Chronic renal failure is a progressive deterioration of the kidneys, but cats can also experience acute renal failure when their kidneys abruptly cease functioning. This can be caused by urinary obstructions, infection, trauma, and the ingestion of toxins. Cats in acute renal failure experience an abrupt shutdown of kidney function and need immediate medical intervention  if they are to survive.

How is CRF diagnosed?

Keeping your cat's pearly whites free of plaque can prevent kidney damage.

There are several conditions with symptoms similar to those seen in cats with CRF. The only way to know for sure is to have your veterinarian run laboratory tests checking your cat’s blood chemistries and ability to concentrate urine. It is also recommended to screen for high blood pressure, especially in geriatric cats and those who are suspect for kidney disease.


The Cat Doctor is a full service medical and surgical facility exclusively for cats. Established in 1983, in the Art Museum area of Philadelphia, the hospital has served the Philadelphia community well for over twenty years, providing excellent comprehensive and compassionate care.

The Cat Doctor also works closely with local rescues and animal welfare organisations.

The practice maintains an active Facebook page

Check back next week for more information about CRF!


About colvillevalleyanimalsanctuary

The Colville Valley Animal Sanctuary is an all-volunteer organization dedicated to the rescue and rehabilitation of abandoned, neglected, and otherwise homeless companion animals. We provide both crisis and long-term sheltering, medical care, fostering, and adoption services - all with the goal of placing our animals permanently in safe and loving homes. We spay and neuter all of the animals in our care and actively promote, through financial donations and community support, the effort to reduce the number of unwanted animals in Stevens County. By example and through education, we promote and advance the values of responsible pet ownership and the humane treatment of animals.
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